Hoppe-Seyler´s Zeitschrift für physiologische Chemie 1976-11-01

[1-Adamanty fluoroformate, a useful reagent in peptide chemistry (author's transl)].

L Moroder, L Wackerle, E Wünsch

Index: Hoppe. Seylers. Z. Physiol. Chem. 357 , 1647, (1976)

Full Text: HTML

Abstract

1-Adamantyl fluoroformate was prepared from 1-adamantol and fluorophosgene. The cristalline and stable fluoroformate was allowed to react with amino acids to give the corresponding 1-adamantyloxycarbonyl derivatives in consistently high yields. Additonally this new reagent proved to be ideally reactive for acylation of the imidazol function of histidine and histidyl-peptides.