ChemBioChem 2012-09-03

Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.

Lalit Kumar Sharma, Na-Ra Lee, Eun Ryoung Jang, Beilei Lei, Chang-Guo Zhan, Wooin Lee, Kyung-Bo Kim

Index: ChemBioChem. 13(13) , 1899-903, (2012)

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Abstract

Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.