Neurobiology of Aging 1991-01-01

Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents.

G Benzi, O Pastoris, A Gorini, F Marzatico, R F Villa, D Curti

Index: Neurobiol. Aging 12(3) , 227-31, (1991)

Full Text: HTML

Abstract

A severe age-dependent depletion of reduced glutathione (GSH) occurs in rat forebrain at 1-3 h from intraperitoneal injection of the electrophilic agents cyclohexene-1-one and cycloheptene-1-one. Chronic pretreatment with central dopamine agonists (i.e., ergot alkaloids; particularly, dihydroergocriptine) partially counteracts the GSH depletion induced in 15-month-old forebrains by the prooxidants tested. In contrast, chronic pretreatment with a vasodilator agent (i.e., papaverine) magnifies the GSH depletion.