Acta Pharmaceutica Hungarica 1990-01-01

[Polarographic determination of diaveridine in biological samples].

P Tömpe, G Giegler

Index: Acta Pharm. Hung. 60(1) , 23-9, (1990)

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Abstract

Differential pulse polarographic method was applied for determination of diaveridine in plasma, whole blood and isolated organs (liver, spleen, kidney, thymus). Deproteinization of homogenized blood and organs had been carried out on Extrelut column and then concentration of diaveridine was determined by measuring peak current at EP = -1100 mV peak potential on pulse polarogram in 10(-3) mol/dm-3 perchloric acid. The developed procedure--which has been validated by gas chromatographic method--has been suitable to determination of acid concentrations and pharmacokinetic curves.