Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

M Artico, R Silvestri, G Stefancich, L Avigliano…

Index: Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228

Full Text: HTML

Citation Number: 20

Abstract

Abstract New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H- imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o, m, p)-substituent in the phenyl ring; an analogous series of p-substituted phenylhydrazides with 5 or 6-membered heterocyclic ring as substituent, and a series of similar phenylpropionic hydrazides. The longer and ...

 Related Synthetic Route
(4-(1H-1,2,4-Triazol-1-yl)phenyl)methanol Structure

143426-50-0

(4-(1H-1,2,4-Tr...

~90%

1-(4-(CHLOROMETHYL)PHENYL)-1H-1,2,4-TRIAZOLE Structure

143426-53-3

1-(4-(CHLOROMET...

4-(1H-PYRROL-1-YL)BENZYL ALCOHOL Structure

143426-51-1

4-(1H-PYRROL-1-...

~84%

4-(1H-Pyrrol-1-yl)benzaldehyde Structure

23351-05-5

4-(1H-Pyrrol-1-...

Imidazole Structure

288-32-4

Imidazole

Ethyl 4-Fluorobenzoate Structure

451-46-7

Ethyl 4-Fluorob...

~52%

Ethyl 4-(1H-imidazol-1-yl)benzoate Structure

86718-07-2

Ethyl 4-(1H-imi...

1-iodo-3-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]-oct-1-ene Structure

51061-63-3

1-iodo-3-[[(1,1...

~%

2-(4-(Pyridin-2-yl)phenyl)acetic acid Structure

51061-67-7

2-(4-(Pyridin-2...

2-p-tolylpyridine Structure

4467-06-5

2-p-tolylpyridine

~%

2-(4-(Pyridin-2-yl)phenyl)acetic acid Structure

51061-67-7

2-(4-(Pyridin-2...

2-[4-(Bromomethyl)phenyl]pyridine Structure

52199-24-3

2-[4-(Bromometh...

~%

2-(4-(Pyridin-2-yl)phenyl)acetic acid Structure

51061-67-7

2-(4-(Pyridin-2...

Ethyl 4-(1H-imidazol-1-yl)benzoate Structure

86718-07-2

Ethyl 4-(1H-imi...

~56%

[4-(1H-Imidazol-1-yl)phenyl]methanol Structure

86718-08-3

[4-(1H-Imidazol...

ETHYL 4-(1H-PYRAZOL-1-YL)BENZOATE Structure

143426-47-5

ETHYL 4-(1H-PYR...

~%

2-(4-(1H-PYRAZOL-1-YL)PHENYL)ACETIC ACID Structure

65476-24-6

2-(4-(1H-PYRAZO...

Ethyl 4-Fluorobenzoate Structure

451-46-7

Ethyl 4-Fluorob...

~%

2-(4-(1H-PYRAZOL-1-YL)PHENYL)ACETIC ACID Structure

65476-24-6

2-(4-(1H-PYRAZO...

(4-Pyrazol-1-ylphenyl)methanol Structure

143426-49-7

(4-Pyrazol-1-yl...

~%

2-(4-(1H-PYRAZOL-1-YL)PHENYL)ACETIC ACID Structure

65476-24-6

2-(4-(1H-PYRAZO...

[4-(1H-Imidazol-1-yl)phenyl]methanol Structure

86718-08-3

[4-(1H-Imidazol...

~51%

4-Imidazol-1-yl-benzaldehyde Structure

10040-98-9

4-Imidazol-1-yl...

(4-(1H-1,2,4-Triazol-1-yl)phenyl)methanol Structure

143426-50-0

(4-(1H-1,2,4-Tr...

~48%

4-[1,2,4]Triazol-1-yl-benzaldehyde Structure

27996-86-7

4-[1,2,4]Triazo...

Ethyl 4-Fluorobenzoate Structure

451-46-7

Ethyl 4-Fluorob...

~%

4-[1,2,4]Triazol-1-yl-benzaldehyde Structure

27996-86-7

4-[1,2,4]Triazo...

Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate Structure

143426-48-6

Ethyl 4-(1H-1,2...

~%

4-[1,2,4]Triazol-1-yl-benzaldehyde Structure

27996-86-7

4-[1,2,4]Triazo...

Ethyl 4-(1H-imidazol-1-yl)benzoate Structure

86718-07-2

Ethyl 4-(1H-imi...

~72%

Benzoic acid, 4-(1H-imidazol-1-yl)-, hydrazide Structure

96717-21-4

Benzoic acid, 4...

Ethyl 4-Fluorobenzoate Structure

451-46-7

Ethyl 4-Fluorob...

~%

Benzoic acid, 4-(1H-imidazol-1-yl)-, hydrazide Structure

96717-21-4

Benzoic acid, 4...

ETHYL 4-(1H-PYRAZOL-1-YL)BENZOATE Structure

143426-47-5

ETHYL 4-(1H-PYR...

~89%

(4-Pyrazol-1-ylphenyl)methanol Structure

143426-49-7

(4-Pyrazol-1-yl...

1,2,4-Triazole Structure

288-88-0

1,2,4-Triazole

Ethyl 4-Fluorobenzoate Structure

451-46-7

Ethyl 4-Fluorob...

~48%

Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate Structure

143426-48-6

Ethyl 4-(1H-1,2...

Pyrazole Structure

288-13-1

Pyrazole

Ethyl 4-Fluorobenzoate Structure

451-46-7

Ethyl 4-Fluorob...

~74%

ETHYL 4-(1H-PYRAZOL-1-YL)BENZOATE Structure

143426-47-5

ETHYL 4-(1H-PYR...

[1,1'-Biphenyl]-4-carboxylicacid, ethyl ester Structure

6301-56-0

[1,1'-Biphenyl]...

~83%

4-Biphenylcarboxylic acid hydrazide Structure

18622-23-6

4-Biphenylcarbo...

(4-Pyrazol-1-ylphenyl)methanol Structure

143426-49-7

(4-Pyrazol-1-yl...

~90%

4-Pyrazol-1-yl-benzaldehyde Structure

99662-34-7

4-Pyrazol-1-yl-...

Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate Structure

143426-48-6

Ethyl 4-(1H-1,2...

~77%

(4-(1H-1,2,4-Triazol-1-yl)phenyl)methanol Structure

143426-50-0

(4-(1H-1,2,4-Tr...

Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate Structure

143426-48-6

Ethyl 4-(1H-1,2...

~98%

4-(1,2,4-triazol-1-yl)benzohydrazide Structure

58419-68-4

4-(1,2,4-triazo...

Ethyl 4-Fluorobenzoate Structure

451-46-7

Ethyl 4-Fluorob...

~%

4-(1,2,4-triazol-1-yl)benzohydrazide Structure

58419-68-4

4-(1,2,4-triazo...

Imidazole Structure

288-32-4

Imidazole

Ethyl 2-fluorobenzoate Structure

443-26-5

Ethyl 2-fluorob...

~42%

Ethyl 2-(1H-imidazol-1-yl)benzoate Structure

117296-92-1

Ethyl 2-(1H-imi...

4-Cyanobenzyl bromide Structure

17201-43-3

4-Cyanobenzyl b...

~%

4-(pyrrol-1-ylmethyl)benzoic acid Structure

137025-10-6

4-(pyrrol-1-ylm...

4-(1H-pyrrol-1-ylmethyl)benzonitrile Structure

143426-60-2

4-(1H-pyrrol-1-...

~%

4-(pyrrol-1-ylmethyl)benzoic acid Structure

137025-10-6

4-(pyrrol-1-ylm...


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