4-Hydroxy-1, 2, 5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at …

…, A Gasco, B Nielsen, TN Johansen

Index: Zimmermann, Diane; Janin, Yves Louis; Brehm, Lotte; Braeuner-Osborne, Hans; Ebert, Bjarke; Johansen, Tommy Norskov; Madsen, Ulf; Krogsgaard-Larsen, Povl European Journal of Medicinal Chemistry, 1999 , vol. 34, # 11 p. 967 - 976

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Citation Number: 11

Abstract

In order to investigate the 4-hydroxy-1, 2, 5-oxadiazol-3-yl moiety as a carboxylic acid bioisoster at ionotropic glutamate receptors (iGluRs), a series of acidic α-aminocarboxylic acids in which the distal carboxy group was replaced by the 4-hydroxy-1, 2, 5-oxadiazol-3-yl