Toxicology Letters 1986-11-01

Mutagenicity of 4-nitrodiphenyl ether and its metabolites.

R L Gupta, D K Dey, T R Juneja

Index: Toxicol. Lett. 34(1) , 13-21, (1986)

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Abstract

The mutagenic potential of 4-nitrodiphenyl ether (NDE) an intermediate of herbicides and an anthelmintic drug, and its reduced products (-NO, -NHOH) were investigated in the Ames test. All the three compounds were potent direct-acting base-pair and frameshift mutagens with activity order -NHOH greater than -NO greater than -NO2. The -NHOH compound has been considered to be the penultimate/ultimate mutagen.