Synthesis and biological evaluation of some 6-substituted purines

…, ES Coimbra, M de Oliveira Matos, AML Carmo…

Index: Braga, Fernanda Gambogi; Coimbra, Elaine Soares; de Oliveira Matos, Magnum; Lino Carmo, Arturene Maria; Cancio, Marisa Damato; da Silva, Adilson David European Journal of Medicinal Chemistry, 2007 , vol. 42, # 4 p. 530 - 537

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Citation Number: 24

Abstract

We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6- substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3′-chloropropylthio) purine 2 (DA Benson, I. Karsch-Mizrachi, DJ Lipman, J. Ostell, BA Rapp, DL Wheeler, Genbank. Nucleic Acids Res. 28 (2000) 15–18; EV Aleksandrova, PMIE Valashek, J. Med. Pharm. Chem. 35 (2001) 172–173), 6-(3′-( ...