Chemical & Pharmaceutical Bulletin 2001-04-01

Synthesis of new fused pyrimidines by isocyanate and isothiocyanate.

A Z Chowdhury, Y Shibata

Index: Chem. Pharm. Bull. 49(4) , 391-5, (2001)

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Abstract

o-Aminonitrile or o-aminoester compounds were cyclized to fused pyrimidines by reacting with ethyl iso(thio)cyanatoacetate in pyridine, and then were methylated, halogenated and subsequently displaced by the amines studied.

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