Enantiomers of 1-ethyl-7-[3-[(ethylamino) methyl]-1-pyrrolidinyl]-6, 8-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity

TP Culbertson, JM Domagala, JB Nichols…

Index: Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W. Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715

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Citation Number: 27

Abstract

0022-2623/87/1830-1711 $01.50/0 0 1 zoxazine or quinolizine rings. In all cases, most if not all of the activity (lO-lOO-fold!) was present in just one enantiomer. Since fewer quinolones contain chiral side chains, much less has been reported on the influence of side-chain asymmetry on antibacterial activity. In just one case, the enantiomeric quinolones with 2- substituted pyrrolidinyl side chains were synthesized. Once again, one isomer (6) ...