Ramiro Maravilla-Galván, Reyna Fierro, Humberto González-Márquez, Sandra Gómez-Arroyo, Irma Jiménez, Miguel Betancourt
Index: Int. J. Toxicol. 28(1) , 24-32, (2009)
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Atrazine is a herbicide of the chloro-s-triazine family. It inhibits photosynthesis in plants and is an endocrine disruptor, but its effects on human health are controversial. Fenoxaprop-ethyl, an aryloxy phenoxyalkanoic acid herbicide, inhibits the biosynthesis of fatty acids and provokes depolarization of membranes. The aim of this study is to evaluate the in vitro effects of both herbicides on capacitation, spontaneous acrosome reaction (SAR) and progesterone-induced acrosome reaction (PIAR) in boar sperm. Sperm capacitation is done in TALP-HEPES media for 4 hours. Capacitation and SAR are evaluated immediately; PIAR, 30 minutes later. LC50 for fenoxaprop-ethyl is 60 micromolar [corrected] and 40 micromolar [corrected] for atrazine. Fenoxaprop-ethyl induces capacitation at 60 micromolar [corrected] and SAR at all concentrations, also increases significantly PIAR. Atrazine decreased capacitation whereas increase significantly SAR and PIAR at all concentrations. It seems that fenoxaprop-ethyl and atrazine accelerate the capacitation and the acrosomal reaction, possibly via plasma membrane destabilization.
Structure | Name/CAS No. | Molecular Formula | Articles |
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fenoxaprop-ethyl
CAS:66441-23-4 |
C18H16ClNO5 |
Effect of herbicides on glutathione S-transferases in the ea...
2008-03-01 [Environ. Sci. Pollut. Res. Int. 15(2) , 143-9, (2008)] |
Chiral separation of three agrochemical toxins enantiomers b...
2007-03-01 [Biomed. Chromatogr. 21(3) , 234-40, (2007)] |
Persistence of herbicide fenoxaprop ethyl and its acid metab...
2013-01-01 [J. Environ. Sci. Health B 48(5) , 324-30, (2013)] |
Isolation of the fenoxaprop-ethyl (FE)-degrading bacterium R...
2011-10-01 [FEMS Microbiol. Lett. 323(2) , 196-203, (2011)] |
Influence of toxicity and dissipation of racemic fenoxaprop ...
2008-01-01 [J. Environ. Sci. Health B 43(3) , 231-6, (2008)] |
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