Journal of Organic Chemistry 2006-09-01

Synthesis of 3-fluoroazetidines.

Willem Van Brabandt, Guido Verniest, Dirk De Smaele, Guillaume Duvey, Norbert De Kimpe

Index: J. Org. Chem. 71 , 7100, (2006)

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Abstract

N-(Alkylidene or 1-arylmethylidene)-2-propenylamines were regiospecifically functionalized to novel N-(alkylidene or 1-arylmethylidene)-3-bromo-2-fluoropropylamines, which were proven to be excellent precursors for 3-fluoroazetidines.