Journal of Pharmaceutical and Biomedical Analysis 1989-01-01

Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B.

M Subhashini, M S Subramanian, V R Rao

Index: J. Pharm. Biomed. Anal. 7(12) , 1473-7, (1989)

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Abstract

A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 micrograms of INH can be determined.