Biological & Pharmaceutical Bulletin 2003-03-01

Isolation of nitrophenols from diesel exhaust particles (DEP) as vasodilatation compounds.

Yoki Mori, Kazuyuki Kamata, Noriko Toda, Hideyuki Hayashi, Koh-ichi Seki, Shinji Taneda, Shin Yoshino, Akiyo Sakushima, Masakatsu Sakata, Akira K Suzuki

Index: Biol. Pharm. Bull. 26(3) , 394-395, (2003)

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Abstract

The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities.