Synthesis and biological activity of novel substituted pyridines and purines containing 2, 4-thiazolidinedione

…, SK Kang, JH Lee, JS Shin, SK Ahn, CI Hong…

Index: Kim, Bok Young; Ahn, Joong Bok; Lee, Hong Woo; Kang, Sung Kwon; Lee, Jung Hwa; Shin, Jae Soo; Ahn, Soon Kil; Hong, Chung Il; Yoon, Seung Soo European Journal of Medicinal Chemistry, 2004 , vol. 39, # 5 p. 433 - 447

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Citation Number: 121

Abstract

A series of substituted pyridines and purines containing 2, 4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a–d, 12a–e, 18a–d, 23a–c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKAy mice in vivo. On the basis of their ...