Journal of the American Chemical Society

Organocatalytic asymmetric reaction cascade to substituted cyclohexylamines

J Zhou, B List

Index: Zhou, Jian; List, Benjamin Journal of the American Chemical Society, 2007 , vol. 129, # 24 p. 7498 - 7499

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Citation Number: 205

Abstract

We report a new strategy for organocatalytic cascade reactions. Accordingly, enamine catalysis, iminium catalysis, and Brønsted acid catalysis can work in concert in a highly enantioselective organocatalytic cascade sequence toward chiral cis-3-substituted cyclohexylamines. We found that an achiral amine in combination with a catalytic amount of a chiral Brønsted acid can accomplish an aldol addition-dehydration-conjugate reduction- ...

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