Tetrahedron letters

Reaction of 1, 2-dihalogen substituted arenes with lanthanum metal: a new generation method of benzyne

H Kawabata, T Nishino, Y Nishiyama, N Sonoda

Index: Kawabata, Hiroshi; Nishino, Toshiki; Nishiyama, Yutaka; Sonoda, Noboru Tetrahedron Letters, 2002 , vol. 43, # 28 p. 4911 - 4913

Full Text: HTML

Citation Number: 20

Abstract

In order to know the reactivity of other lanthanoid metals, 1-chloro-2-iodobenzene was allowed to react with various lanthanoid metals in the presence of excess amount of furan (30 equiv.) at 25°C for 4 h, and these results are shown in Table 1. Although the use of Ce, Pr, Nd, and Yb led to the formation of 2, the yield was decreased. In the case of samarium metal, which is widely used in organic synthesis, the yield of 2 was very low owing to the formation of various ...