Journal of Medicinal Chemistry 2006-07-27

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

Stephen J Baker, Yong-Kang Zhang, Tsutomu Akama, Agnes Lau, Huchen Zhou, Vincent Hernandez, Weimin Mao, M R K Alley, Virginia Sanders, Jacob J Plattner

Index: J. Med. Chem. 49(15) , 4447-50, (2006)

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Abstract

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.