Angewandte Chemie. International edition in English 2013-11-18

Nickel-catalyzed sonogashira reactions of non-activated secondary alkyl bromides and iodides.

Jun Yi, Xi Lu, Yan-Yan Sun, Bin Xiao, Lei Liu

Index: Angew. Chem. Int. Ed. Engl. 52(47) , 12409-13, (2013)

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Abstract

A nicked reaction: The title reaction of terminal alkynes with non-activated secondary alkyl iodides and bromides was accomplished for the first time. This reaction provides a new and practical approach for the synthesis of substituted alkynes (see scheme; cod=cyclo-1,5-octadiene). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.