IARC scientific publications 1980-01-01

Nitrosation of dialkylamines in the presence of bile acid conjugates.

Y K Kim, S R Tannenbaum, J S Wishnok

Index: IARC Sci. Publ. (31) , 207-14, (1980)

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Abstract

The rate of nitrosation of dihexylamine is enhanced when the reaction is carried ut in the presence of micelles containing bile acid conjugates or bile acid conjugates and lecithin. The nitrosation of smaller dialkylamines is not affected. The nitrosation of dihexylamine under these conditions is inhibited by alpha-tocopherol at pH 3 or pH 5. At pH 3 the reaction is inhibited by ascorbic acid, while at pH 5 it is inhibited by equimolar concentrations of ascorbic acid, but accelerated by higher concentration of ascorbic acid. The effect of ascorbic acid at pH 5 depends on the presence of oxygen and sulfamate.