Combinatorial optimization of isatin-β-thiosemicarbazones as anti-poxvirus agents

MC Pirrung, SV Pansare, KD Sarma…

Index: Pirrung, Michael C.; Pansare, Sunil V.; Das Sarma, Koushik; Keith, Kathy A.; Kern, Earl R. Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 3045 - 3050

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Citation Number: 105

Abstract

Novel strategies are required to combat pox virus infections, whether caused by escape of viruses such as monkeypox from indigenous areas or intentional release of smallpox. Anti- smallpox drugs with a unique mode of antiviral action, inhibition of transcription termination, were known but not therapeutically useful. Using a combinatorial method, variants of the basic isatin-β-thiosemicarbazone structure were prepared and examined for cytotoxicity ...