International Journal of Molecular Sciences 2009-01-01

Structural antitumoral activity relationships of synthetic chalcones.

Cesar Echeverria, Juan Francisco Santibañez, Oscar Donoso-Tauda, Carlos A Escobar, Rodrigo Ramirez-Tagle

Index: Int. J. Mol. Sci. 10 , 221-31, (2009)

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Abstract

Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.