Journal of Medicinal Chemistry 2007-10-18

Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.

David Rennison, Adrian P Neal, Gerta Cami-Kobeci, Mario D Aceto, Fernando Martinez-Bermejo, John W Lewis, Stephen M Husbands

Index: J. Med. Chem. 50(21) , 5176-82, (2007)

Full Text: HTML

Abstract

A new series of ligands has been synthesized where the cinnamoyl group of the 14-cinnamoylamino morphinones has been introduced to the 7alpha-substituent of the 6,14-bridged oripavine series. In vitro the compounds were mostly low efficacy partial agonists or antagonists with some selectivity for the mu opioid receptor, with evidence of micro efficacy in vivo. The similarity in SAR between these 6,14-bridged oripavines and the 14-cinnamoylamino series suggests a similar mode of interaction with the micro opioid receptor.