Fitoterapia

Design, synthesis and biological evaluation of paclitaxel-mimics possessing only the oxetane D-ring and side chain structures

XX Chen, F Gao, Q Wang, X Huang, D Wang

Index: Chen, Xing-Xiu; Gao, Feng; Wang, Qi; Huang, Xing; Wang, Dan Fitoterapia, 2014 , vol. 92, p. 111 - 115

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Citation Number: 8

Abstract

Abstract Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure–activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than paclitaxel, but which still represented the first example of simplified paclitaxel analogues with significant anti-tumor ...