Toxicology Letters 1984-10-01

Disposition of [14C]2,3-dichloropropene in Fischer-344 rats after oral or intraperitoneal administration.

M A Medinsky, J A Bond, J S Dutcher, L S Birnbaum

Index: Toxicol. Lett. 23(1) , 119-25, (1984)

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Abstract

2,3-Dichloropropene (2,3-DCP), a component of commercial fumigants and nematocides, was mixed with [14C]2,3-DCP and given to rats by peroral (p.o.) or intraperitoneal (i.p.) administration. Urine, feces, and expired air were collected over 72 h. Excretion of radioactivity in urine predominated over other routes, with 66% to 75% of the dose excreted in 72 h. Feces contained from 13% to 21% of dose. 8% of the dose was exhaled as 14CO2. At the end of 72 h, only 2% to 3% of the dose remained in the carcass with the highest concentrations of 14C in liver, kidney, testes, and lung. Approx. 91% of the p.o. dose was absorbed from the gastrointestinal (GI) tract.