Molecules 2005-01-01

Synthesis of thiadiazoles and 1,2,4-triazoles derived from cyclopropane dicarboxylic acid.

A Hussain K Sharba, Rida H Al-Bayati, Nadjet Rezki, Mohammed R Aouad

Index: Molecules 10(9) , 1153-60, (2005)

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Abstract

New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2). Cyclopropane dicarboxylic acid thiosemicarbazide (6) was converted into 1,1-bis(3-thio-4H-1,2,4-triazol-5-yl) cyclo- propane (7) by ring closure in an alkaline medium. The thiadiazole 2 and the triazole 7 were converted into a variety of derivatives.