Bioscience, Biotechnology, and Biochemistry 2000-03-01

Synthesis of 2,2-diphenylpropionate derivatives and their effects on larval growth of the silkworm.

N Toyomura, I H Kim, T Yoshida, T Shiotsuki, E Kuwano

Index: Biosci. Biotechnol. Biochem. 64(3) , 610-2, (2000)

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Abstract

A variety of 2,2-diphenylpropionate derivatives with an amino substituent were synthesized and their effects on larval growth of the silkworm, Bombyx mori, were examined by dietary administration. Of the compounds tested, 3-(4-ethylpiperazin-1-yl)propyl 2,2-diphenylpropionate (3) caused significant prolongation of the larval period. Studies on the structure-activity relationship indicate that a piperazine ring and the bond distances between the nitrogen atom and the ester group were important for this activity. Treatment of compound 3 delayed the increase of ecdysteroid titers in the hemolymph by 3 days compared with that of the control, which correlates with the delay in molting.