Journal of Antibiotics 1991-12-01

Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization.

K Kojiri, M Ihara, S Nakajima, K Kawamura, K Funaishi, M Yano, H Suda

Index: J. Antibiot. 44(12) , 1342-7, (1991)

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Abstract

Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized 125I-ET-1 binding to a porcine aortic smooth muscle membrane, were isolated from the mycelium of a strain of Streptomyces misakiensis. These binding inhibitors were extracted with methanol from mycelium and purified by HPLC.