Bioorganic & Medicinal Chemistry 2001-04-01

Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.

J F Cavalier, M Burton, F Dussart, C Marchand, J F Rees, J Marchand-Brynaert

Index: Bioorg. Med. Chem. 9(4) , 1037-44, (2001)

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Abstract

A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.