Organic Letters 2010-10-15

Bis-exo-2-norbornylboron triflate for stereospecific enolization of 3,3,3-trifluoropropionates.

P Veeraraghavan Ramachandran, Gowrisankar Parthasarathy, Pravin D Gagare

Index: Org. Lett. 12(20) , 4474-7, (2010)

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Abstract

The first boron-mediated enolization-aldolization of 3,3,3-trifluoropropionates has been reported. The preparation and application of bis-exo-bicyclo[2.2.1]heptan-2-ylboron triflate as a superior reagent for diastereospecific enolization has also been described.