Natural Product Research 2013-01-01

A novel and other bioactive secondary metabolites from a marine fungus Penicillium oxalicum 0312F1.

Shuo Shen, Wei Li, Jian Wang

Index: Nat. Prod. Res. 27(24) , 2286-91, (2013)

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Abstract

A new compound 2-(4-hydroxybenzoyl) quinazolin-4(3H)-one (1) and four known compounds were isolated from a marine fungus Penicillium oxalicum 0312F1. The structure of the new compound 1 was elucidated based on the spectroscopic analysis. Bioactivity assays showed that 2-(4-hydroxybenzyl) quinazolin-4(3H)-one (2) and methyl 4-hydroxyphenylacetate (5) had potent inhibitory activity against tobacco mosaic virus (TMV), and the new compound 1 had moderate inhibitory activity against TMV and human gastric cancer cell SGC-7901.