Acta poloniae pharmaceutica 2003-01-01

Preliminary evaluation of anticonvulsant activity of some 4-(benzyloxy)-benzamides.

Henryk Marona, Edward Szneler

Index: Acta Pol. Pharm. 60(6) , 477-80, (2003)

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Abstract

A series of alkanolamides have been tested for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure treshold (ScMet) assays and for neurotoxicity (TOX) in rodents. Most interesting were the anticonvulsant results of 2N-methylaminoethanol derivative II, which displayed anti-MES activity (mice) with a protective index (TD50/ED50) of 2.536 higher than that for valproate.