Frontiers in Bioscience 2007-01-01

Electrochemical studies oxidation of ciprofloxacin at nano-SnO2/PVS modified electrode and its interaction with calf thymus DNA.

Yuejuan Cai, Yuzhong Zhang, Shao Su, Suping Li, Yonghong Ni

Index: Front. Biosci. 12 , 1946-55, (2007)

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Abstract

In pH 6.0 phosphate buffer solutions (PBS), a glassy carbon electrode (GCE) modifying by nano-tin oxide/polyvinyl sulfonic potassium (nano-SnO2/PVS) exhibited an enhanced effectiveness for the oxidation of ciprofloxacin (CFX), which compared with a bare GCE or a nano-SnO2 modified electrode. In addition we also investigated the electrooxidation mechanism of the fluoroquinolone antibiotics (utilizing ciprofloxacin, ofloxacin, sparfloxacin and lomefloxacin) at the modified electrode. Furthermore, gel electrophoresis coupled with electrochemistry and spectra techniques were used to study the interaction of CFX and calf thymus DNA (ctDNA). These acquired data showed that the binding mode of CFX and DNA was mainly an intercalation mechanism.