Organic Letters 2006-01-05

Vinylation of aryl bromides using an inexpensive vinylpolysiloxane.

Scott E Denmark, Christopher R Butler

Index: Org. Lett. 8 , 63, (2006)

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Abstract

[reaction: see text] A mild and general method for the palladium-catalyzed vinylation of aryl bromides has been developed. The use of tetrabutylammonium fluoride (TBAF) as the activator and an inexpensive and nontoxic vinyl donor, 1,3,5,7-tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane (D(4)(V), 1), allows for a general and high-yielding preparation of substituted styrenes.