Biological Chemistry Hoppe-Seyler 1985-12-01

[2-Chloro-1-methylpyridinium iodide. A suitable reagent for peptide synthesis].

W Keese, H Khalaf, D Grambow, G Grundke, M Rimpler

Index: Biol. Chem. Hoppe-Seyler 366(12) , 1093-5, (1985)

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Abstract

2-Chloro-1-methylpyridinium iodide is a coupling reagent for peptide synthesis. By its use different peptides were synthesized with protected di- and trifunctional amino acids. While urethan-protected amino acids react free of racemization, the fragment condensation needs N-Hydroxysuccinimide, as shown by the Young test.