Efficient and Chemoselective Reduction of Pyridines to Tetrahydropyridines and Piperidines via Rhodium??Catalyzed Transfer Hydrogenation

J Wu, W Tang, A Pettman, J Xiao

Index: Wu, Jianjun; Tang, Weijun; Pettman, Alan; Xiao, Jianliang Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 35 - 40

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Citation Number: 20

Abstract

Abstract Promoted by iodide anion the rhodium complex dimer,[Cp* RhCl 2] 2, catalyzes efficiently the transfer hydrogenation of various quaternary pyridinium salts under mild conditions, affording not only piperidines but also 1, 2, 3, 6-tetrahydropyridines in a highly chemoselective fashion, depending on the substitution pattern at the pyridinium ring. The reduction is conducted in azeotropic formic acid/triethylamine (HCOOH-Et 3 N) mixture at ...