Journal of Medicinal Chemistry 1976-02-01

Synthesis of N-hydroxythiourea.

M Sato, C H Stammer

Index: J. Med. Chem. 19(2) , 336-7, (1976)

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Abstract

The synthesis of the title compound (1) was accomplished by the conversion of 2,4-dimethoxybenzylamine (2) into an isothiocyanate (3) using thiocarbonyl diimidazole. Treatment of 3 with hydroxylamine and removal of the DMB group with trifluoroacetic acid gave 1. N-Hydroxythiourea (1) showed no activity in the L1210 mouse tumor.