Diane C Cabelof, Julian J Raffoul, Yubin Ge, Holly Van Remmen, Larry H Matherly, Ahmad R Heydari
Index: J. Gerontol. A. Biol. Sci. Med. Sci. 61(5) , 427-34, (2006)
Full Text: HTML
Young (4- to 6-month-old) and aged (24- to 28-month-old) mice were exposed to 2-nitropropane (2-NP), a DNA oxidizing agent, and the ability to induce DNA polymerase beta (beta-pol) and AP endonuclease (APE) was determined. In contrast to the inducibility of these gene products in response to oxidative damage in young mice, aged mice showed a lack of inducibility of beta-pol and APE. APE protein level and endonuclease activity were both reduced 40% (p<.01) in response to 2-NP. Accordingly, the accumulation of DNA repair intermediates in response to 2-NP differed with age. Young animals accumulated 3'OH-containing DNA strand breaks, whereas the aged animals did not. A role for p53 in the difference in DNA damage response with age is suggested by the observation that the accumulation of p53 protein in response to DNA damage in young animals was absent in the aged animals. Our results are consistent with a reduced ability to process DNA damage with age.
Structure | Name/CAS No. | Molecular Formula | Articles |
---|---|---|---|
![]() |
2-Nitropropane
CAS:79-46-9 |
C3H7NO2 |
Affinity chromatographic selection of carbonylated proteins ...
2005-04-15 [Anal. Chem. 77(8) , 2386-92, (2005)] |
Formaldehyde-releasers in cosmetics: relationship to formald...
2010-01-01 [Contact Dermatitis 62(1) , 18-31, (2010)] |
Evaluation of carcinogenic responses in the Eker rat followi...
2002-01-01 [Toxicol. Pathol. 30(5) , 559-64, (2002)] |
Ultraviolet photodissociation dynamics of the n-propyl and i...
2015-06-14 [J. Chem. Phys. 142 , 224306, (2015)] |
Reversal of enantioselectivity by tuning the conformational ...
2010-04-01 [Angew. Chem. Int. Ed. Engl. 49(15) , 2772-6, (2010)] |
Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer
Copyright © 2024 ChemSrc All Rights Reserved