Archives Internationales de Pharmacodynamie et Therapie 1980-09-01

Effects of halopemide on potassium-induced release of radiolabeled neurotransmitters from rat cerebrocortical slices in vitro.

A J Loonen, W Soudijn

Index: Arch. Int. Pharmacodyn. Ther. 247(1) , 43-58, (1980)

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Abstract

The effects of halopemide on the release of 3H-serotonin, 3H-noradrenaline, 3H-acetylcholine and 3H-GABA from rat frontal cortical slices in vitro were studied and compared to those of its neuroleptic congener R29800, spiperone and haloperidol. Spontaneous 3H-serotonin and to a lesser extend 3H-noradrenaline outflow were augmented by the agents, while the effects on basal 3H-acetylcholine and 3H-GABA release were small or absent. Mechanism explaining these effects are discussed. Depolarization-induced release of serotonin was affected more markedly than the extra overflow of other radiolabeled transmitters, but the statistical significant of the response was limited.