International Immunopharmacology 2011-03-01

Immunosuppressive and anti-inflammatory activities of sinomenine.

Quanxing Wang, Xiao-Kang Li

Index: Int. Immunopharmacol. 11(3) , 373-6, (2011)

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Abstract

Sinomenine (SN), a pure compound extracted from the Sinomenium acutum plant, has been found to inhibit T- and B-lymphocyte activation, proliferation and function and to interfere with the differentiation, recruitment and function of several other cell types, such as dendritic cells (DC). SN has demonstrated its potential anti-inflammatory role for treating immune-related disorders in experimental animal models and in some clinical applications. This review will summarize its potential effects, mechanisms and applications.Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.