Cellular and Molecular Biology 2006-01-01

Signal transduction pathways of calcitonin/calcitonin receptor regulating cytoskeletal organization and bone-resorbing activity of osteoclasts.

S Tanaka, H Suzuki, H Yamauchi, I Nakamura, K Nakamura

Index: Cell Mol. Biol. 52 , 19-23, (2006)

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Abstract

Calcitonin is a calcium-regulating peptide hormone that acts directly on osteoclasts and suppresses their function. In this review we will focus on the downstream signaling pathways of calcitonin receptor regulating cytoskeletal organization of osteoclasts. We will also introduce the clinical application of the hormone for metabolic bone diseases.