Organic letters

Copper/Silver-Cocatalyzed Conia-Ene Reaction of Linear β-Alkynic β-Ketoesters

CL Deng, RJ Song, SM Guo, ZQ Wang, JH Li

Index: Deng, Chen-Liang; Song, Ren-Jie; Guo, Sheng-Mei; Wang, Zhi-Qiang; Li, Jin-Heng Organic Letters, 2007 , vol. 9, # 24 p. 5111 - 5114

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Citation Number: 36

Abstract

A novel and general copper/silver catalytic system has been developed for the Conia-ene intramolecular reaction of linear β-alkynic β-ketoesters. In the presence of (CuOTf) 2⊙ C6H6 and AgSbF6 (or AgOAc), a variety of the linear β-alkynic β-ketoesters selectively underwent the Conia-ene intramolecular reaction in moderate to good yields.