Farmakologiia i toksikologiia 1983-01-01

[Mechanism of the microcirculatory effects of ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside].

Ia I Khadzhaĭ, L A Chaĭka

Index: Farmakol. Toksikol. 46(2) , 72-5, (1983)

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Abstract

According to the rheo- and photoplethysmography data, ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside (glivenol, tribenol; 25,250 and 4000 mg/kg i.p.) markedly increases the blood content in hind limbs of rabbits, displaying a tendency towards a decrease in systemic arterial pressure and negligibly raises the body temperature when given in maximal doses, without affecting cardiac activity and respiration. The mechanism of the drug hemodynamic effect revealed is determined by activation of the blood flow in precapillary vessels. This plays an essential role in pathogenetic therapy of microcirculatory and trophic disorders in chronic venous failure.