Journal of Biological Chemistry 1981-08-10

Isolation of adenosine 5'-diphosphate-D-glycero-D-mannoheptose. An intermediate in lipopolysaccharide biosynthesis of Shigella sonnei.

T Kontrohr, B Kocsis

Index: J. Biol. Chem. 256 , 7715-8, (1981)

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Abstract

From a Shigella sonnei R mutant which incorporates into its cell wall lipopolysaccharide D-glycero-D-mannoheptose and contains no L-glycero-D-mannoheptose, a nucleotide-linked sugar was isolated and identified as adenosine 5'-diphosphate-D-glycero-d-mannoheptose by chemical and chromatographic analysis. This intermediary compound is assumed to play a role in heptose biosynthesis of Enterobacteria.