Bioorganic & Medicinal Chemistry Letters 2006-01-15

The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.

Andrew K Takle, Murray J B Brown, Susannah Davies, David K Dean, Gerraint Francis, Alessandra Gaiba, Alex W Hird, Frank D King, Peter J Lovell, Antoinette Naylor, Alastair D Reith, Jon G Steadman, David M Wilson

Index: Bioorg. Med. Chem. Lett. 16(2) , 378-381, (2006)

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Abstract

A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.