Bioorganic & Medicinal Chemistry Letters 2015-01-01

Dibenzazepines and dibenzoxazepines as sodium channel blockers.

Stephen M Lynch, Laykea Tafesse, Kevin Carlin, Parijat Ghatak, Donald J Kyle

Index: Bioorg. Med. Chem. Lett. 25(1) , 43-7, (2015)

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Abstract

We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.