Journal of Pharmaceutical Sciences 1981-11-01

Concentration of perfluorohexyl bromide in dog plasma and selected tissues.

M Scrime, J Edelson

Index: J. Pharm. Sci. 70(11) , 1199-201, (1981)

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Abstract

Beagle dogs received single perfluorohexyl bromide doses, either 30.2 g/kg po or 3.8 g/kg intratracheally. The apparent first-order plasma half-life during the terminal elimination phase was approximately 8 hr after oral treatment and greater than 8 hr after intratracheal administration. Tissue analysis showed the highest mean concentration of the compound in abdominal fat 1 week after intratracheal administration. One dog had detectable levels in abdominal fat 4 weeks after treatment by either administration route.