Journal of Pharmacy and Pharmacology 1994-07-01

Investigation of synergism with combinations of dibromopropamidine isethionate or propamidine isethionate and polymyxin B.

M R Richards, D K Xing

Index: J. Pharm. Pharmacol. 46(7) , 563-6, (1994)

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Abstract

Combinations of polymyxin B and dibromopropamidine isethionate exhibited synergistic inhibitory and bactericidal activity against Pseudomonas aeruginosa, Enterobacter cloacae, Proteus mirabilis, Escherichia coli and Staphylococcus aureus. Similar results were obtained with polymyxin B plus propamidine combinations except that propamidine was not as active as dibromopropamidine and the combination of polymyxin B plus propamidine against S. aureus only had additive activity. The antibacterial agents were tested in solutions and in a cream formulation. The findings indicate a potential for the use of selected combinations of these antibacterial agents in the treatment of wound and superficial eye infections.