Veterinary Quarterly 1987-10-01

Acetylation, deacetylation and hydroxylation of sulphamethoxazole and N4-acetylsulphamethoxazole in the snail Cepaea hortensis.

T B Vree, M L Vree, J F Nouws

Index: Vet. Q. 9(4) , 378-81, (1987)

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Abstract

The snail Cepaea hortensis is able to acetylate and hydroxylate sulphamethoxazole in a similar way to man. About one percent deacetylation, but no hydroxylation of N4-acetysulphamethoxazole takes place. The relative rates of the metabolic pathways for hydroxylation and acetylation of sulphamethoxazole are equal.