Organic Letters 2007-08-02

Medium-sized carbocycles by a zirconocene-catalyzed tandem formal ring expansion-magnesation reaction of alkenyl-substituted cyclic enol ethers.

José Barluenga, Lucía Alvarez-Rodrigo, Félix Rodríguez, Francisco J Fañanás

Index: Org. Lett. 9(16) , 3081-4, (2007)

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Abstract

A new regio- and stereoselective zirconocene-catalyzed reaction for the synthesis of medium-sized rings is described. The global reaction supposes a formal ring expansion of a cyclic enol ether to give a functionalized carbocycle.